OCUNOVIS FAQ

Q: How often does Ocunovis need to be applied?

A: Excellent results with just twice daily application, but can be applied up to four times daily if required.

Q: Do I need to use an antibiotic with Ocunovis?

A: It does not contain an antimicrobial, so if infection is a risk or is suspected, appropriate therapy should be initiated alongside Ocunovis. Consult your veterinarian.

Q: How long does Ocunovis last once opened?

A: There are no preservatives in Ocunovis and this should be considered in relation to the shelf life. It is advised that a bottle is disposed one month after opening.

Q: Can I use Ocunovis in place of cyclosporine?

A: Ocunovis is intended to be used alongside licensed medications such as cyclosporine. It does not slow down the progressive immune destruction of the lacrimal glands as is the licensed indication of cyclosporine. In many cased KCS gland destruction is advanced by the time of diagnosis, so therapy slowing down the destruction of the lacrimal glands may be less effective1, and provision of drops that hydrate and lubricate the eye surface will also be required. Even in dogs that respond well to treatment with cyclosporine, additional tear supplementation is still recommended as this helps keep the eyes as comfortable and pain-free as possible. Consult your veterinarian.

1 Hadzi Milic M, Dordevic J, Krstic N. Cyclosporine A (CsA) treatment of chronic autoimmune-mediated keratoconjunctivitis sicca in dogs. Acta Veterinaria (Beograd). 2013; 5-6(63): 677-685.6.

Q: Are all gel eye drops the same?

A: One of the limitations of many eye drops currently available is the need for very frequent administration (often four to six times daily). This can be a barrier to pet owner compliance whereas the unique structure of Ocunovis application only requires application twice daily2. In addition Ocunovis uses the BioHAnce™ technology. This technology allows for greater therapeutic activity in less volume while lasting longer. This technology has proven in clinical studies to help dramatically reduce symptoms associated with dry eye, irritation, discharge and overall eye health.

In addition this technology creates a shear thin layer of protection that is less likely to interfere with a pet’s comfort when applied and thus a greater likelihood they will more readily allow future applications.

2 Williams D, Mann B. A crosslinked HA based hydrogel ameliorates Dry Eye symptoms in dogs. International Journal of biomaterials Volume 2013 Article ID 460437

Q: But are Hyaluronic Acid eye drops the same as Ocunovis and BioHAnce?

A: The main component in Ocunovis is hyaluronic acid (HA), a non-immunogenic molecule found widely throughout human and animal tissues, HA fulfills many biological functions including: promoting wound healing and helping to reduce scarring3, cushioning and lubrication3, maintaining tissue hydration3. However the rapid degradation of naturally occurring HA in vivo has traditionally limited is clinical applications4. Through advanced technology used in Ocunovis (BioHAnce) it has become possible to modify HA by crosslinking the molecules. The cross-linked HA in Ocunovis is more resistant to degradation4 and thus can last longer than traditional eye drops. In addition the cross-linking technology allows for greater activity of HA in less volume that is not achievable with standard HA. Ocunovis is the only gel eye drops specifically designed for pets that has supporting clinical studies.

3 Chen JWY, Abatangelo G. Functions of hyaluronan in wound repair. Wound Repair and Regeneration 1999; 7:79-89.
4 Yang G, Espandar L, Mamalis N, Prestwich GD. A cross-linked hyaluronan gel accelerates healing of corneal epithelial abrasion and alkali burn injuries in rabbits. Vet Ophthalmol. 2010;13(3) :144–150.

Q: Is Ocunovis safe?

A: Ocunovis is 100% naturally derived and does not contain preservatives or ingredients that would cause pain or stinging.

Q: Can Ocunovis be used for other eye conditions?

A: Ocunovis can be used for dry, irritated eyes and other conditions where long lasting eye lubrication and hydration may be of benefit for dogs and cats.

OCULENIS FAQ

Q: How often should the solutions be applied?

A: Simply apply 1 to 2 drops directly onto the injured eye a minimum of 2 times daily until the eye injury is repaired based on your veterinarian’s recommendations.

EPISANIS FAQ

Q: How often does Episanis need to be applied?

A: A single daily application may be sufficient to help enhance healing and closure in fresh, uncomplicated wounds. More complex injuries, irritations or incisions may require further treatment to accelerate closure. Consult your veterinarian.

Q: Do I need to use an antimicrobial with Episanis?

A: It does not contain an antimicrobial, so if infection is a risk or is suspected, appropriate therapy should be initiated alongside Episanis. Episanis should follow the application of other topical medications, and at least 5 minutes should be left between the application of other products and Episanis.

Q: What makes Episanis help to achieve rapid healing?

A: The main component in Episanis is hyaluronic acid (HA), a non-immunogenic molecule found widely throughout human and animal tissues, HA fulfills many biological functions including: promoting wound healing and helping to reduce scarring3, cushioning and lubrication3, maintaining tissue hydration3.

However the rapid degradation of naturally occurring HA in vivo has traditionally limited is clinical applications4. Through advanced technology used in Episanis (BioHAnce) it has become possible to modify HA by crosslinking the molecules. The cross-linked HA in Episanis is more resistant to degradation4 and thus can last longer while maintaining therapeutic activity. BioHAnce is specifically modified for the epidermal environment. It creates a cellular matrix that naturally enhances the animal’s own healing process by optimizing the epithelial cell activity. It also provides a thin coating on the surface of the skin that helps protect the affected area.

3 Chen JWY, Abatangelo G. Functions of hyaluronan in wound repair. Wound Repair and Regeneration 1999; 7:79-89.
4 Yang G, Espandar L, Mamalis N, Prestwich GD. A cross-linked hyaluronan gel accelerates healing of corneal epithelial abrasion and alkali burn injuries in rabbits. Vet Ophthalmol. 2010;13(3) :144–150.

Q: Is Episanis safe?

A: Episanis is 100% naturally derived and does not contain preservatives or ingredients that would cause pain or stinging. It is safe if licked.

Q: Can Episanis be used for other skin conditions?

A: Episanis is formulated to promote rapid wound closure. It also supports an enhanced healing process of skin from acute injuries, surgical procedures and common skin irritations in dogs and cats, including: superficial wounds (cuts, scratches and abrasions), traumatic injuries (bites, lacerations and punctures), surgical incisions and hot spots: caused by a condition called acute moist dermatitis. They are itchy, painful skin lesions that result from constant licking, biting, and scratching.