Technology
In more than 30 animal studies, SentrX products have been consistently shown to promote healing-even in the most difficult-to-treat cases. Why? It comes down to cells.
Proven Revolutionary Animal Wound Healing Technology
Wound Healing
"Enhanced wound healing in horses and dogs using crosslinked hyaluronic acid-based hydrogel films," Poster presented at the Society for Biomaterials Annual Meeting, Chicago, IL, April 2007. View online
"Glycosaminogycan Hydrogel Films as Biointeractive Dressings for Wound Healing," Biomaterials, 23, 3661-3671 (2002). View online
"Glycosaminoglycan Hydrogels as Supplemental Wound Dressings for Donor Sites," Journal of Burn Care & Rehabilitation, 25(3):276-286, May/June 2004.. View online
"Molecular Stenting with a Crosslinked Hyaluronan Derivative Inhibits Collagen Gel Contraction," Journal of Investigative Dermatology, (2006) 126, 2202-2209. doi:10.1038/sj.jid.5700380;. View online
"Release of Basic Fibroblast Growth Factor from a Crosslinked Glycosaminoglycan Hydrogel Promotes Wound Healing," Wound Rep. Reg., 15, 245-251 (2007).
Adhesion Prevention
"Reduced Post-operative Intra-abdominal Adhesions Using Carbylan TM-SX, a Semi-synthetic Glycosaminoglycan Hydrogel," Fertility and Sterility, Volume 83, Issue 4, Pages 1275-1283. View online
"Chrondroitin Sulfate Hydrogel and Wound Healing in Rabbit Maxillary Sinus Mucosa," Laryngoscope, 114, 1406-1409 (2004). View online
"Crosslinked hyaluronan hydrogels containing mitomycin C reduce postoperative abdominal adhesions," Fertility and Sterility, Volume 83, Issue 4, Pages 1275-1283. View online
"Composition of hyaluronan affects wound healing in the rabbit maxillary sinus," American Journal of Rhinology, Volume 20, Number 2, March-April 2006, pp. 206-211(6). View online
"Reduced Postoperative Intra-abdominal Adhesions Using Carbylan-SX, a Semisynthetic Glycosaminologycan Hydrogel," Fertility and Sterility, 87, 940-948 (2007).
"Postoperative Pericardial Adhesion Prevention Using Carbylan SX in a Rabbit Model," J. Surg. Res., 140, 237-242 (2007).
"Structural Variations in a Single Hyaluronan Derivative Significantly Alter Wound-Healing Effects in the Rabbit Maxillary Sinus," Laryngoscope, 117, 1288-1295 (2007).
"Prevention of Peritendinous Adhesions Following Flexor Tendon Injury with Carbylan-SX, a Semisynthetic Glycosaminoglycan Hydrogel," J. Orthopedic Res., in press (2008).
"A Cross-Linked Hyaluran Gel Accelerates Healing of Corneal Abraision and Alkali Burn Injuries in Rabbits," Vetern. Opthamol., 13, 144-150 (2010).
Orthopedics
"Accelerated Repair of Cortical Bone Defects Using a Synthetic Extracellular Matrix to Deliver Human Demineralized Bone Matrix," J. Orthoped. Res., 24:1454-1462, 2006. View online
"Osteochondral Defect Repair with Autologous Bone Marrow-Derived Mesenchymal Stem Cells in an Injectable, in situ Crosslinked Synthetic Extracellular Matrix," Tissue Eng., 12, 3405-3416 (2006).
"Synthesis, Characterization and Chondroprotective Properties of a Novel Hyaluronan Thioethyl Ether Derivative," Biomaterials, in press (2008).
Tissue Engineering
"Composite Articular Cartilage Engineered on a Chondrocyte-Seeded Aliphatic Polyurethane Sponge," Tissue Engineering, Jul 2004, Vol. 10, No. 7 : 1084 -1092. View online
"Disulfide-crosslinked hyaluronan-gelatin hydrogel films: a covalent mimic of the extracellular matrix for in vitro cell growth.," Biomaterials, 2003 Sep;24(21):3825-34. View online
"Disulfide-crosslinked hyaluronan-gelatin sponge: Growth of fibrous tissue in vivo," Journal of Biomedical Materials Research, 68A, 142-149 (2004). View online
"In situ crosslinkable hyaluronan hydrogels for tissue engineering," Biomaterials, 25, 1339-1348 (2004). View online
"Fibronectin Functional Domains Coupled to Hyaluronan Stimulate Adult Human Dermal Fibroblast Responses Critical for Wound Healing," Tissue Engineering, Mar 2006, Vol. 12, No. 3 : 601 -613. View online
"Vocal Fold Tissue Repair in Vivo Using a Synthetic Extracellular Matrix," Tissue Engineering, 12, 2171-2180 (2006).
"Synthesis and evaluation of injectable, in situ crosslinkable synthetic extracellular matrices for tissue engineering," Journal of Biomedical Materials Research, 79A, 902-912 (2006). View online
"Development of a Model Bladder Extracellular Matrix Combining Disulfide Cross-linked Hyaluronan with Decellularized Bladder Tissue," Macromol. Biosci., 6, 648-657 (2006).
"Injectable Synthetic Extracellular Matrices for Tissue Engineering and Repair," Adv. Exp. Med. Biol., 585, 125-133 (2006). View online
"Tumor Engineering: Orthotopic Cancer Models in Mice Using Cell-Loaded, Injectable, Cross-linked Hyaluronan Derived Hydrogels," Tissue Engineering, 13, 1091-1101 (2007).
"Influence of Cross-Linked Hyaluronic Acid Hydrogels on Neurite Outgrowth and Recovery from Spinal Cord Injury," J. Neurosurg. Spine, 6, 133-140 (2007).
"Bioprinting Living Structures," J. Mater. Chem., 17, 2054-2060 (2007).
"Simplifying the Extracellular Matrix for 3-D Cell Culture and Tissue Engineering: A Pragmatic Approach," J. Cell. Biochem., 101, 1370-1383 (2007).
"Adipose Tissue Engineering with Naturally-derived Scaffolds and Adipose-derived Stem Cells," Biomaterials, 28, 3834-3842 (2007).
"Effects of Synthetic Extracellular Matrices on Primary Human Fibroblast Behavior," Acta Biomaterialia, 4, 67-75 (2008).
"Synthetic Extracellular Matrix Enhances Tumor Growth and Metastasis in an Orthotopic Mouse Model of Pancreatic Adenocarcinoma," J. Gastrointest. Surg., in press (2008).
"Emergence of Solid Scaffold-free, Bioreactor-free, and Cell-free In Vivo Tissue Engineering: Directed Tissue Assembly by Centrifugal Casting," Exp. Opin. Biol. Ther., in press (2008).
Molecule Release
"Injectable Glycosaminoglycan Hydrogels for Controlled Release of Human Basic Fibroblast Growth Factor," Biomaterials, 2005 Oct;26(30):6054-67. Epub 2005 Apr 22.. View online
"Dual Growth Factor-Induced Angiogenesis In Vivo Using Hyaluronan Hydrogel Implants," Biomaterials, 2006 Mar;27(9):1868-75. Epub 2005 Oct 21. View online
"Heparin-regulated release of growth factors in vitro and angiogenic response in vivo to implanted hyaluronan hydrogels containing VEGF and bFGF," Biomaterials, 2006 Oct;27(30):5242-51. Epub 2006 Jun 30. View online
"Stimulation of in vivo angiogenesis using dual growth factor-loaded crosslinked glycosaminoglycan hydrogels," Biomaterials, 2006 Dec;27(35):5935-43. Epub 2006 Sep 6. View online
General
"Disulfide Cross-Linked Hyaluronan Hydrogels," Biomacromolecules, 3, 1304 -1311, 2002. View online
"Biocompatibility and stability of disulfide-crosslinked hyaluronan films," Biomaterials, 2005 Aug;26(23):4737-46. View online
"Rheological Characterization of in Situ Cross-Linkable Hyaluronan Hydrogels," Biomacromolecules, 6 (5), 2857 -2865, 2005. 10.1021/bm050361c S1525-7797(05)00361-2. View online
"Synthesis of Hyaluronan Haloacetates and Biology of Novel Cross-Linker-Free Synthetic Extracellular Matrix Hydrogels," Biomacromolecules, 8, 2821-2828 (2007).
"Synthesis and Characterization of Novel Thiol-Reactive Poly(ethylene glycol) Cross-linkers for Extracellular-Matrix-Mimetic Biomaterials," Biomacromolecules, 8, 2883-2889 (2007).
"Chemically-Modified HA for Therapy and Regenerative Medicine," Curr. Pharm. Biotech., in press (2008).
"Evaluating Drug Toxicity and Efficacy in Three Dimensions: Using Synthetic Extracellular Matrices in Drug Discovery," Acc. Chem. Res., in press (2008).
"Making Modular Extracellular Matrices: Solutions for the Puzzle," Methods in Extracellular Matrix Research, in press (2008).
