Scientific Studies

In more than 50 animal studies, SentrX products have been consistently shown to promote healing-even in the most difficult-to-treat cases. Why? It comes down to cells.

Proven Revolutionary Animal Wound Healing Technology


Ophthalmology

Williams, David L. Ph.D., DVM; Mann, Brenda K. PhD. "A crosslinked HA-based Hydrogel Ameliorates Dry Eye Symptoms in Dogs," International J. Biomaterials, 2013, 8 pages, http//dx.doi.org/10.1155/2013/460435.

G. Yang, L. Espandar, N. Mamalis and G.D. Prestwich, "A Cross-Linked Hyaluran Gel Accelerates Healing of Corneal Abraision and Alkali Burn Injuries in Rabbits," Vetern. Opthamol., 13, 144-150 (2010).

Williams DL, Mann BK (2014) "Efficacy of a Crosslinked Hyaluronic Acid-Based Hydrogel as a Tear Film Supplement: A Masked Controlled Study." PLoS ONE 9(6): e99766. doi:10.1371/journal.pone.0099766 View online

Wirostko Barbara, Mann Brenda K., Williams David L., and Prestwich Glenn D."Ophthalmic Uses of a Thiol-Modified Hyaluronan-Based Hydrogel". Advances in Wound Care. November 2014, 3(11): 708-716. doi:10.1089/wound.2014.0572. View online

Wound Healing

Dahlgren, Linda A., Milton, Stewart C., Boswell, Stacie G., Were, Stephen R., Brewster, Carlyle C., Jones, Christine S. and Crisman, Mark. “Evaluation of a Hyaluronic Acid-Based Biomaterial to Enhance Wound Healing in the Equine Distal Limb." J. Equine Vet. Sci. 44:90-99 (2016).

Jann, Henry W., Hart, James C., Stein, Larry E. Ritchey, Jerry, Blaik, Margaret, Payton, Mark, Fackelman, Gustave E., Rezabek, Grant B. and Mann, Brenda. "The Effects of a Crosslinked Modified Hyaluronic Acid (xCMHA-S) Gel on Equine Tendon Healing." Vet. Surgery. 45:231-239 (2016).

Prestwich, Glenn D. Ph.D.  "Clinical Biomaterials for Scar-Free Healing and Localized Delivery of Cells and Growth Factoirs,"  Adv. Wound Care, 2010, 1:394-399.

Kirker, K. R. BSE; Luo, Y. PhD; J.H. Nielson, Shelby, J. PhD; Prestwich, G. D. PhD, "Glycosaminogycan Hydrogel Films as Biointeractive Dressings for Wound Healing," Biomaterials, 23, 3661-3671 (2002). View online

Kirker, K. R. BSE; Luo, Y. PhD; Morris, S. E. MD; Shelby, J. PhD; Prestwich, G. D. PhD, "Glycosaminoglycan Hydrogels as Supplemental Wound Dressings for Donor Sites," Journal of Burn Care & Rehabilitation, 25(3):276-286, May/June 2004.. View online

Tanuj D Mehra1, Kaustabh Ghosh, Xiao Zheng Shu, Glenn D Prestwich, and Richard A F Clark, "Molecular Stenting with a Crosslinked Hyaluronan Derivative Inhibits Collagen Gel Contraction," Journal of Investigative Dermatology, (2006) 126, 2202-2209. doi:10.1038/sj.jid.5700380;. View online

Y. Liu, S. Cai, X.Z. Shu, J. Shelby, and G.D. Prestwich, "Release of Basic Fibroblast Growth Factor from a Crosslinked Glycosaminoglycan Hydrogel Promotes Wound Healing," Wound Rep. Reg., 15, 245-251 (2007).

Yang G, Prestwich GD, Mann BK, “Thiolated carboxymethyl hyaluronic acid-based biomaterials enhance wound healing in rats, dogs, and horses,” ISRN Veterinary Science, Volume 2011, Article ID 851593, 7 pages.

Adhesion Prevention

Y. Liu, H. Li, X. Shu, S. Gray, G. Prestwich, "Reduced Post-operative Intra-abdominal Adhesions Using Carbylan TM-SX, a Semi-synthetic Glycosaminoglycan Hydrogel," Fertility and Sterility, Volume 83, Issue 4, Pages 1275-1283 (2005). View online

M.E. Guilbert, K.R. Kirker, S.D. Gray, P.D. Ward, J.G. Szakacs, G.D. Prestwich, and R.R. Orlandi, "Chrondroitin Sulfate Hydrogel and Wound Healing in Rabbit Maxillary Sinus Mucosa," Laryngoscope, 114, 1406-1409 (2004). View online

Y. Liu, H. Li, X. Shu, S. Gray, G. Prestwich, "Crosslinked hyaluronan hydrogels containing mitomycin C reduce postoperative abdominal adhesions," Fertility and Sterility, Volume 83, Issue 4, Pages 1275-1283. View online

Proctor, Matthew; Proctor, Kerry; Shu, Xiao Zheng; McGill, Lawrence D.; Prestwich, Glenn D.; Orlandi, Richard R., "Composition of hyaluronan affects wound healing in the rabbit maxillary sinus," American Journal of Rhinology, Volume 20, Number 2, March-April 2006, pp. 206-211(6). View online

Y. Lui, X.Z. Shu, and G.D. Prestwich, "Reduced Postoperative Intra-abdominal Adhesions Using Carbylan-SX, a Semisynthetic Glycosaminologycan Hydrogel," Fertility and Sterility, 87, 940-948 (2007).

R.C. Connors, J.J. Muir, Y. Liu, G.R. Reiss, P.C. Kouretas, M.G Whitten, T.K. Sorenson, G.D. Prestwich, and D.A. Bull, "Postoperative Pericardial Adhesion Prevention Using Carbylan SX in a Rabbit Model," J. Surg. Res., 140, 237-242 (2007).

R.R. Orlandi, X.Z. Shu, L. McGill, E. Petersen, and G.D. Prestwich, "Structural Variations in a Single Hyaluronan Derivative Significantly Alter Wound-Healing Effects in the Rabbit Maxillary Sinus," Laryngoscope, 117, 1288-1295 (2007).

Y. Liu, A. Skardal, X.Z. Shu, and G.D. Prestwich, "Prevention of Peritendinous Adhesions Following Flexor Tendon Injury with Carbylan-SX, a Semisynthetic Glycosaminoglycan Hydrogel," J. Orthopedic Res., 26, 562-9 (2008).

Orthopedics

G.D. Prestwich, "Accelerated Repair of Cortical Bone Defects Using a Synthetic Extracellular Matrix to Deliver Human Demineralized Bone Matrix," J. Orthoped. Res., 24:1454-1462, 2006. View online

Y. Liu, X.Z. Shu, and G.D. Prestwich, "Osteochondral Defect Repair with Autologous Bone Marrow-Derived Mesenchymal Stem Cells in an Injectable, in situ Crosslinked Synthetic Extracellular Matrix," Tissue Eng., 12, 3405-3416 (2006).

M.A. Serban, G. Yang, and G.D. Prestwich, "Synthesis, Characterization and Chondroprotective Properties of a Novel Hyaluronan Thioethyl Ether Derivative," Biomaterials, 29, 1388-99 (2008).

Tissue Engineering

Yanchun Liu, Ken Webb, Kelly R. Kirker, Nicole J. Bernshaw, Patrick A. Tresco, Steven D. Gray, Glenn D. Prestwich, "Composite Articular Cartilage Engineered on a Chondrocyte-Seeded Aliphatic Polyurethane Sponge," Tissue Engineering, Jul 2004, Vol. 10, No. 7 : 1084 -1092. View online

Xiao Zheng Shu, Yanchun Liu, Glenn D. Prestwich, and F. Palumbo, "Disulfide-crosslinked hyaluronan-gelatin hydrogel films: a covalent mimic of the extracellular matrix for in vitro cell growth.," Biomaterials, 2003 Sep;24(21):3825-34. View online

Yanchun Liu, Xiao Zheng Shu, Steven D. Gray, Glenn D. Prestwich, "Disulfide-crosslinked hyaluronan-gelatin sponge: Growth of fibrous tissue in vivo," Journal of Biomedical Materials Research, 68A, 142-149 (2004). View online

X.Z. Shu, Y. Liu, F. Palumbo, Y. Luo, G.D. Prestwich, "In situ crosslinkable hyaluronan hydrogels for tissue engineering," Biomaterials, 25, 1339-1348 (2004). View online

K. Ghosh, X.D. Ren, X.Z. Shu, G.D. Prestwich, and R.A.F. Clark, "Fibronectin Functional Domains Coupled to Hyaluronan Stimulate Adult Human Dermal Fibroblast Responses Critical for Wound Healing," Tissue Engineering, Mar 2006, Vol. 12, No. 3 : 601 -613. View online

S. Duflo, S.L. Thibeault, W. Li, X.Z. Shu, and G.D. Prestwich, "Vocal Fold Tissue Repair in Vivo Using a Synthetic Extracellular Matrix," Tissue Engineering, 12, 2171-2180 (2006).

X.Z. Shu, S. Ahmad, Y. Liu, and G.D. Prestwich, "Synthesis and evaluation of injectable, in situ crosslinkable synthetic extracellular matrices for tissue engineering," Journal of Biomedical Materials Research, 79A, 902-912 (2006). View online

A. L. Brown, e.M. Srokowskki, X.Z. Shu, G.D. Prestwich and K.A. Woodhouse, "Development of a Model Bladder Extracellular Matrix Combining Disulfide Cross-linked Hyaluronan with Decellularized Bladder Tissue," Macromol. Biosci., 6, 648-657 (2006).

G.D. Prestwich, X.Z. Shu, Y. Liu, S. Cai, J.F. Walsh, C.W. Hughes, S. Ahmad, K.R. Kirker, B. Yu, R.R. Orlandi, A.H. Park, S.L. Thibeault, and M.E. Smith, "Injectable Synthetic Extracellular Matrices for Tissue Engineering and Repair," Adv. Exp. Med. Biol., 585, 125-133 (2006). View online

Y. Liu, X.Z. Shu, and G.D. Prestwich, "Tumor Engineering: Orthotopic Cancer Models in Mice Using Cell-Loaded, Injectable, Cross-linked Hyaluronan Derived Hydrogels," Tissue Engineering, 13, 1091-1101 (2007).

E.M. Horn, M. Beaumont, X.Z. Shu, A. Harvey, G.D. Prestwich, K.M. Horn, A.R. Gibson, M.C. Preul, and A. Panitch, "Influence of Cross-Linked Hyaluronic Acid Hydrogels on Neurite Outgrowth and Recovery from Spinal Cord Injury," J. Neurosurg. Spine, 6, 133-140 (2007).

V. Mironov, G.D. Prestwich, and G. Forgacs, "Bioprinting Living Structures," J. Mater. Chem., 17, 2054-2060 (2007).

G.D. Prestwich, "Simplifying the Extracellular Matrix for 3-D Cell Culture and Tissue Engineering: A Pragmatic Approach," J. Cell. Biochem., 101, 1370-1383 (2007).

L. Flynn, G.D. Prestwich, J.L. Semple, and K.A. Woodhouse, "Adipose Tissue Engineering with Naturally-derived Scaffolds and Adipose-derived Stem Cells," Biomaterials, 28, 3834-3842 (2007).

M.A. Serban, Y. Liu, and G.D. Prestwich, "Effects of Synthetic Extracellular Matrices on Primary Human Fibroblast Behavior," Acta Biomaterialia, 4, 67-75 (2008).

V. Mironov, V. Kasyanov, R.R. Markwald and G.D. Prestwich, Bioreactor-free Tissue Engineering: Directed Tissue Assembly by Centrifugal Casting," Exp. Opin. Biol. Ther., 8, 143-52 (2008).

Lawyer T, McIntosh K, Clavijo C, Potekhina L, Mann BK, "Formulation Changes Affect Material Properties and Cell Behavior in HA-based Hydrogels," International Journal of Cell Biology, Volume 2012, Article ID 737421, 9 pages.

Molecule Release

S. Cai, Y. Liu, X.Z. Shu, and G.D. Prestwich, "Injectable Glycosaminoglycan Hydrogels for Controlled Release of Human Basic Fibroblast Growth Factor," Biomaterials, 2005 Oct;26(30):6054-67. Epub 2005 Apr 22.. View online

R.A. Peattie, E. Rieke, E. Hewett, R.J. Fisher, X.Z. Shu, and G.D. Prestwich, "Dual Growth Factor-Induced Angiogenesis In Vivo Using Hyaluronan Hydrogel Implants," Biomaterials, 2006 Mar;27(9):1868-75. Epub 2005 Oct 21. View online

Pike DB, Cai S, Pomraning KR, Firpo MA, Fisher RJ, Shu XZ, Prestwich GD, Peattie RA, "Heparin-regulated Release of Growth Factors In-vitro and Angiogenic Response In-vivo to Implanted Hyaluronan Hydrogels Containing VEGF and BFGF," Biomaterials, 2006 Oct;27(30):5242-51. Epub 2006 Jun 30. View online

Riley CM, Fuegy PW, Firpo MA, Shu XZ, Prestwich GD, Peattie RA, "Stimulation of in vivo angiogenesis using dual growth factor-loaded crosslinked glycosaminoglycan hydrogels," Biomaterials, 2006 Dec;27(35):5935-43. Epub 2006 Sep 6. View online

Bhakta G, Rai B, Lim ZX, Hui JH, Stein GS, van Wijnen AJ, Nurcombe V, Prestwich GD, Cool SM, “Hyaluronic Acid-Based Hydrogels Functionalized with Heparin that Support Controlled Release of Bioactive BMP-2,”Biomaterials, 33, 6113-22 (2012).

General

Xiao Zheng Shu, Yanchun Liu, Yi Luo, Meredith C. Roberts, and Glenn D. Prestwich, "Disulfide Cross-Linked Hyaluronan Hydrogels," Biomacromolecules, 3, 1304 -1311, 2002. View online

Liu Y, Zheng Shu X, Prestwich GD, "Biocompatibility and stability of disulfide-crosslinked hyaluronan films," Biomaterials, 2005 Aug;26(23):4737-46. View online

Kaustabh Ghosh, Xiao Zheng Shu, Robert Mou, Jack Lombardi, Glenn D. Prestwich, Miriam H. Rafailovich, and Richard A. F. Clark, "Rheological Characterization of in Situ Cross-Linkable Hyaluronan Hydrogels," Biomacromolecules, 6 (5), 2857 -2865, 2005. 10.1021/bm050361c S1525-7797(05)00361-2. View online

M.A. Serban and G.D. Prestwich, "Synthesis of Hyaluronan Haloacetates and Biology of Novel Cross-Linker-Free Synthetic Extracellular Matrix Hydrogels," Biomacromolecules, 8, 2821-2828 (2007).

J.L. Vanderhooft, B.K. Mann, and G.D. Prestwich, "Synthesis and Characterization of Novel Thiol-Reactive Poly(ethylene glycol) Cross-linkers for Extracellular-Matrix-Mimetic Biomaterials," Biomacromolecules, 8, 2883-2889 (2007).

G.D. Prestwich and J.W. Kuo, "Chemically-Modified HA for Therapy and Regenerative Medicine," Curr. Pharm. Biotech., 9,242-5 (2008).

G.D. Prestwich, "Evaluating Drug Toxicity and Efficacy in Three Dimensions: Using Synthetic Extracellular Matrices in Drug Discovery," Acc. Chem. Res., 41, 139-48 (2008).

Vanderhooft JL, Alcoutlabi M, Magda JJ, Prestwich GD, “Rheological Properties of Cross-linked Hyaluronan-Gelatin Hydrogels for Tissue Engineering,”Macromolecular Bioscience, 9, 20-8 (2009).

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