Animal Health Care & Wound Healing Technology
In more than 30 animal studies, SentrX animal health care and wound healing products have been consistently shown to promote healing-even in the most difficult-to-treat cases. Why? It comes down to cells.
How SentrX works
When tissue is healthy, its extracellular matrix (ECM) provides support for cells and regulates intercellular communication. When an injury occurs, signals are released from the tissue that stimulate cells to repair the injury. Unfortunately, the process often leads to the formation of scar tissue rather than the appropriate new ECM. SentrX products provide matrices that work with the animal's natural repair system to encourage enhanced production of the appropriate ECM, leading to new healthy tissue.
SentrX technology consists of chemically modified glycosaminoglycans (GAGs), natural components of the ECM, that are crosslinked to form a matrix. Each formulation is specifically designed for a particular tissue in order to provide the optimal matrix for healing of that tissue.
SentrX products crosslink proprietary biopolymers to create matrices for enhanced healing of tissues.
Animal-specific solutions
Unlike many veterinary products that are derived from human treatments, SentrX biomaterials are created specifically for animals. Because of this, SentrX products are fully biocompatible and do not elicit immune stimulation, local or systemic toxicity, or inflammation.
Treatments beyond wound care
In addition, the chemically functionalized polymers in SentrX technology can be crosslinked to a variety of other molecules. Crosslinking between modified GAGs and other ECM proteins can be precisely determined and controlled. Not only does this make SentrX products effective alone, they may be used in conjunction with other treatments to deliver growth factors, drugs, or autologous cells.
Studies involving SentrX technologies
Enhanced wound healing in horses and dogs using crosslinked hyaluronic acid-based hydrogel films.
Poster presented at the Society for Biomaterials Annual Meeting, Chicago, IL, April 2007.
Mann BK, Scott JA, Rees R, Brown J, Seppi M, Burns G, Prestwich GD.
Glycosaminoglycan Hydrogels as Supplemental Wound Dressings for Donor Sites
Journal of Burn Care & Rehabilitation. 25(3):276-286, May/June 2004.
Kirker, K. R. BSE; Luo, Y. PhD; Morris, S. E. MD; Shelby, J. PhD; Prestwich, G. D. PhD
Blycosaminogycan Hydrogel Films as Biointeractive Dressings for Wound Healing
Biomaterials, 23, 3661 3671 (2002)
Kirker, K. R. BSE; Luo, Y. PhD; J.H. Nielson, Shelby, J. PhD; Prestwich, G. D. PhD
Chrondroitin Sulfate Hydrogel and Wound Healing in Rabbit Maxillary Sinus Mucosa
Laryngoscope, 114, 1406-1409 (2004)
M.E. Guilbert, K.R. Kirker, S.D. Gray, P.D. Ward, J.G. Szakacs, G.D. Prestwich, and R.R. Orlandi
Accelerated Repair of Cortical Bone Defects Using a Synthetic Extracellular Matrix to Deliver Human Demineralized Bone Matrix
J Orthop Res 24:1454-1462, 2006
Yanchun Liu, Shama Ahmad, Xiao Zheng Shu, R. Kent Sanders, Sally Anne Kopesec, Glenn D. Prestwich
Reduced Post-operative Intra-abdominal Adhesions Using Carbylan TM-SX, a Semi-synthetic Glycosaminoglycan Hydrogel
Fertility and Sterility,Volume 83,Issue 4,Pages 1275-1283
Y. Liu, H. Li, X. Shu, S. Gray, G. Prestwich
